期刊
BMC MUSCULOSKELETAL DISORDERS
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12891-021-04231-7
关键词
Vitamin B-12; Rotator cuff; Degenerative; Tear
资金
- National Research Foundation of Korea (NRF) - Korea government (MSIT) [2019R1F1A1061015, 2019R1A2C4070492, 2019R1C1C1004017]
- National Research Foundation of Korea [2019R1A2C4070492, 2019R1F1A1061015] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
The study found that low serum levels of Vitamin B-12 were independently associated with degenerative rotator cuff tears. Further research is needed to determine if Vitamin B-12 supplementation can reduce the risk of this condition.
BackgroundVitamin B-12 (Vit B-12) deficiency results in elevated homocysteine levels and interference with collagen cross-linking, which may affect tendon integrity. The purpose of this study was to investigate whether serum Vit B-12 levels were correlated with degenerative rotator cuff (RC) tear.MethodsEighty-seven consecutive patients with or without degenerative RC tear were enrolled as study participants. Possible risk factors (age, sex, medical history, bone mineral density, and serum chemistries including glucose, magnesium, calcium, phosphorus, zinc, homocysteine, Vitamin D, Vit B-12, homocysteine, and folate) were assessed. Significant variables were selected based on the results of univariate analyses, and a logistic regression model (backward elimination) was constructed to predict the presence of degenerative RC tear.ResultsIn the univariate analysis, the group of patients with degenerative RC tear had a mean concentration of 528.4pg/mL Vit B-12, which was significantly lower than the healthy control group (627.1pg/mL). Logistic regression analysis using Vit B-12 as an independent variable revealed that Vit B-12 concentrations were significantly correlated with degenerative RC tear (p =0.044). However, Vit B-12 levels were not associated with tear size.ConclusionLow serum levels of Vit B-12 were independently related to degenerative RC tear. Further investigations are warranted to determine if Vit B-12 supplementation can decrease the risk of this condition.
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