期刊
BMC GENOMICS
卷 22, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12864-021-07570-w
关键词
GWAS; Transcriptomics; Feed conversion ratio; Pigs; Pathways; Hypothalamus
资金
- National Natural Science Foundation of China [31802039]
- Fundamental Research Funds for the Central Universities [2662020DKPY005]
- Major Science and Technology Projects in Hubei Province [2020ABA016]
- National Swine Industry Technology System [CARS-35]
- Natural Science Foundation of Jingmen City [2020YFYB045]
- Jingchu University of Technology [QDJ201902]
The study identified candidate genes TPH2, GRIP1, FRS2, TRHDE, and CNOT2 for regulating FCR in Yorkshire pigs, potentially affecting intestinal motility, appetite, and metabolism through various signaling pathways.
Background The feed conversion ratio (FCR) is an important productive trait that greatly affects profits in the pig industry. Elucidating the genetic mechanisms underpinning FCR may promote more efficient improvement of FCR through artificial selection. In this study, we integrated a genome-wide association study (GWAS) with transcriptome analyses of different tissues in Yorkshire pigs (YY) with the aim of identifying key genes and signalling pathways associated with FCR. Results A total of 61 significant single nucleotide polymorphisms (SNPs) were detected by GWAS in YY. All of these SNPs were located on porcine chromosome (SSC) 5, and the covered region was considered a quantitative trait locus (QTL) region for FCR. Some genes distributed around these significant SNPs were considered as candidates for regulating FCR, including TPH2, FAR2, IRAK3, YARS2, GRIP1, FRS2, CNOT2 and TRHDE. According to transcriptome analyses in the hypothalamus, TPH2 exhibits the potential to regulate intestinal motility through serotonergic synapse and oxytocin signalling pathways. In addition, GRIP1 may be involved in glutamatergic and GABAergic signalling pathways, which regulate FCR by affecting appetite in pigs. Moreover, GRIP1, FRS2, CNOT2, and TRHDE may regulate metabolism in various tissues through a thyroid hormone signalling pathway. Conclusions Based on the results from GWAS and transcriptome analyses, the TPH2, GRIP1, FRS2, TRHDE, and CNOT2 genes were considered candidate genes for regulating FCR in Yorkshire pigs. These findings improve the understanding of the genetic mechanisms of FCR and may help optimize the design of breeding schemes.
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