期刊
BMC CANCER
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12885-021-08260-2
关键词
Rectal cancer; Vitamin D; Sex; Inflammation; Survival
类别
资金
- South-Eastern Norway Regional Health Authority [2015033, 2018054, 2016050]
In this study, it was found that low vitamin D levels are associated with prognosis in rectal cancer patients, with an impact on disease severity and survival rates.
BackgroundWe reported previously that rectal cancer patients given curative-intent chemotherapy, radiation, and surgery for non-metastatic disease had enhanced risk of metastatic progression and death if circulating levels of 25-hydroxyvitamin D [25(OH) D] were low. Here we investigated whether the association between the vitamin D status and prognosis pertains to the general, unselected population of rectal cancer patients.MethodsSerum 25(OH) D at the time of diagnosis was assessed in 129 patients, enrolled 2013-2017 and representing the entire range of rectal cancer stages, and analyzed with respect to season, sex, systemic inflammation, and survival.ResultsIn the population-based cohort residing at latitude 60 degrees N, 25(OH) D varied according to season in men only, who were overrepresented among the vitamin D-deficient (<50nmol/L) patients. Consistent with our previous findings, the individuals presenting with T4 disease had significantly reduced 25(OH) D levels. Low vitamin D was associated with systemic inflammation, albeit with distinct modes of presentation. While men with low vitamin D showed circulating markers typical for the systemic inflammatory response (e.g., elevated erythrocyte sedimentation rate), the corresponding female patients had elevated serum levels of interleukin-6 and the chemokine (C-X-C motif) ligand 7. Despite disparities in vitamin D status and the potential effects on disease attributes, significantly shortened cancer-specific survival was observed in vitamin D-deficient patients irrespective of sex.ConclusionThis unselected rectal cancer cohort confirmed the interconnection of low vitamin D, more advanced disease presentation, and poor survival, and further suggested it may be conditional on disparate modes of adverse systemic inflammation in men and women.Trial registrationClinicalTrials.govNCT01816607; registration date: 22 March 2013.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据