期刊
BMC CANCER
卷 21, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12885-021-08153-4
关键词
Prognosis; Liver cancer; Neutrophil-to-lymphocyte ratio; Platelet distribution width
类别
资金
- 2020 Anhui Medical University School Fund [2020xkj180]
This study investigated the prognostic value of the combination of neutrophil to lymphocyte ratio and platelet distribution width in post-operation patients with resectable hepatocellular carcinoma. The results demonstrated that this combination index is a valuable biomarker for predicting the survival of patients with HCC.
Background: As is well recognized that inflammation plays a crucial role in the genesis and progression of various cancer. Here we investigate the prognostic value of a novel index: the combination of neutrophil to lymphocyte ratio and platelet distribution width (coNLR-PDW) in post-operation patients with resectable hepatocellular carcinoma (HCC). Methods: The receiver operating characteristic (ROC) curve was utilized to determine the optimal cutoff values of continuous variables, including the neutrophil-lymphocyte ratio (NLR) and platelet distribution width (PDW). Kaplan-Meier method and the Log-rank test were used to compare survival differences across three groups stratified by the coNLR-PDW score. Univariate and multivariate Cox proportional hazard regression analyses were adopted to identify independent factors of HCC patient's prognosis. Results: 1.59 and 13.0 were perceived as the optimal cutoff value for NLR and PDW based on the ROC curve, respectively. Kaplan-Meier method revealed that a higher coNLR-PDW score predicts poorer overall survival (OS) and disease-free survival (DFS) (P < 0.001). coNLR-PDW was demonstrated as an independent factor for both OS and DFS using Cox regression analysis in training and validation cohort. Conclusion: coNLR-PDW is recognized as a valuable biomarker for predicting the survival of patients with HCC.
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