Clinical outcomes observation in stage IIB-IIIB cervical cancer treated by adjuvant surgery following concurrent chemoradiotherapy

BackgroundTo explore the feasibility of adjuvant surgery following concurrent chemoradiation therapy (CCRT) in stage IIB-IIIB (according to FIGO staging of 2009) cervical cancer and analyze risk factors of recurrence after surgery.MethodsForty-nine patients diagnosed with stage IIB-IIIB cervical cancer were reviewed retrospectively. We investigated the risk factors of recurrence after surgery using Chi-squared Test and further analyzed multiple factors affecting postoperative recurrence using the multi-factor logistic regression. Furthermore, the correlation of surgery outcomes (including operation time, bleeding, and hospitalization date and surgery complications) with the time which carried out between CCRT and completion surgery was analyzed.ResultsTumor histology and residual tumor in the cervix were significantly associated with postoperative recurrence (P=0.014 and P=0.040, respectively). Logistic regression analysis demonstrated that the independent risk factors of postoperative recurrence were age and residual tumor in the cervix (P=0.017 and P=0.030, respectively). Complications (operation time, bleeding, hospitalization date) were compared between patients with an interval with radiotherapy less than 6weeks and patients with an interval longer than 6weeks. There were statistical differences in the amount of bleeding and postoperative complications between the two groups (P=0.019 and P=0.044, respectively).ConclusionCCRT combined with surgery for stage IIB-IIIB cervical cancer was feasible, reduced the rate of postoperative recurrence and surgery complications were tolerated.

Automated summary

The study found that tumor histology and residual tumor in the cervix were significantly associated with postoperative recurrence, and identified age and residual tumor in the cervix as independent risk factors. Compared to patients with an interval longer than 6 weeks, patients with an interval of less than 6 weeks had statistically significant differences in bleeding and postoperative complications.