A cornucopia of research resources for the fourth rodent malaria parasite species

Review Immunology

Modeling Relapsing Malaria: Emerging Technologies to Study Parasite-Host Interactions in the Liver

Annemarie Voorberg-van der Wel et al.

Summary: Recent studies on liver stage malaria parasite-host interactions have shed light on the intricate cross-talk between the parasite and its mammalian host, particularly focusing on the interactions between hypnozoites and hepatocytes. Understanding these interactions may help identify factors that could awaken dormant parasite reservoirs, potentially leading to the total eradication of malaria.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2021)

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Article Biology

Plasmodium vinckei genomes provide insights into the pan-genome and evolution of rodent malaria parasites

Abhinay Ramaprasad et al.

Summary: Through extensive genetic and phenotype analysis of P. vinckei, it was found that the five subspecies have diverged widely and undergone large-scale genome rearrangements. Region-specific selection pressures were observed particularly on genes involved in mosquito transmission. The highland forest subspecies P. v. vinckei has a smaller genome and reduced multigene family repertoire, making it suitable for transfection and ideal for reverse genetics research. Amenable to genetic crosses, P. vinckei isolates show a large degree of phenotypic and genotypic diversity. Their inclusion in studies provides new insights into the evolution of RMPs and multigene families, making them valuable resources for research on parasite virulence and immunogenicity.

BMC BIOLOGY (2021)

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Review Parasitology