Prothrombotic immune thrombocytopenia after COVID-19 vaccination

Review Pharmacology & Pharmacy

Intravenous Immune Globulin (IVIG) for Treatment of Autoimmune Heparin-Induced Thrombocytopenia: A Systematic Review

John A. Dougherty et al.

Summary: The effectiveness of IVIG in treating aHIT patients was evaluated, showing good results in increasing platelet count and a favorable platelet recovery within 5 days after IVIG administration.

ANNALS OF PHARMACOTHERAPY (2021)

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Article Medicine, General & Internal

Safety and efficacy of the ChAdOx1 nCoV-19 vaccine (AZD1222) against SARS-CoV-2: an interim analysis of four randomised controlled trials in Brazil, South Africa, and the UK

Merryn Voysey et al.

Summary: The ChAdOx1 nCoV-19 vaccine has been shown to have an acceptable safety profile and effectiveness against symptomatic COVID-19, with higher efficacy observed in the group that received a low dose followed by a standard dose.

LANCET (2021)

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Article Hematology

Immunotherapy for COVID-19: Evolving treatment of viral infection and associated adverse immunological reactions

Jeffrey S. Putter

Summary: This review discusses the COVID-19 immunotherapy and compares the major vaccines currently approved. Pfizer and Moderna's double dose vaccines have shown better treatment efficacy, while AstraZeneca's vaccine has advantages in terms of cost and storage.

TRANSFUSION AND APHERESIS SCIENCE (2021)

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News Item Multidisciplinary Sciences

WHAT SCIENTISTS DO AND DON'T KNOW ABOUT THE OXFORD-ASTRAZENECA COVID VACCINE

Heidi Ledford et al.

NATURE (2021)

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Article Medicine, General & Internal

Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination

Andreas Greinacher et al.

Summary: After vaccination with ChAdOx1 nCov-19, rare immune thrombotic thrombocytopenia can occur due to platelet-activating antibodies against PF4, resulting in various thrombotic events. Most patients in this case series were women, with fatal outcomes such as cerebral venous thrombosis and intracranial hemorrhage. Additional studies are needed to further investigate and understand this phenomenon.

NEW ENGLAND JOURNAL OF MEDICINE (2021)

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Review Hematology