期刊
BIOPHYSICAL JOURNAL
卷 120, 期 19, 页码 4182-4192出版社
CELL PRESS
DOI: 10.1016/j.bpj.2021.03.025
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资金
- research program The Active Matter Physics of Collective Metastasis - Dutch Research Council (NWO)
This review article focuses on the importance and research status of cell-cell adhesion, including descriptions and regulations at different levels, as well as discussions on the molecular and cellular mechanisms of cell-cell adhesion.
Intercellular adhesion is the key to multicellularity, and its malfunction plays an important role in various developmental and disease-related processes. Although it has been intensively studied by both biologists and physicists, a commonly accepted definition of cell-cell adhesion is still being debated. Cell-cell adhesion has been described at the molecular scale as a function of adhesion receptors controlling binding affinity, at the cellular scale as resistance to detachment forces or modulation of surface tension, and at the tissue scale as a regulator of cellular rearrangements and morphogenesis. In this review, we aim to summarize and discuss recent advances in the molecular, cellular, and theoretical description of cell-cell adhesion, ranging from biomimetic models to the complexity of cells and tissues in an organismal context. In particular, we will focus on cadherin-mediated cell-cell adhesion and the role of adhesion signaling and mechanosensation therein, two processes central for understanding the biological and physical basis of cell-cell adhesion.
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