期刊
BIOMEDICINE & PHARMACOTHERAPY
卷 137, 期 -, 页码 -出版社
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
DOI: 10.1016/j.biopha.2021.111285
关键词
5-FU resistance; Cancer stemness; Angiogenesis; DNA repair; MDR modulators; Combination therapy
资金
- Rajiv Gandhi National fellowship (RGNF)
5-Fluorouracil (5-FU) is a crucial anti-cancer drug, but drug resistance has hindered its clinical efficacy. Overcoming chemoresistance, especially caused by cancer stem cells, remains a challenge.
5-Fluorouracil (5-FU) has been an important anti-cancer drug to date. With an increase in the knowledge of its mechanism of action, various treatment modalities have been developed over the past few decades to increase its anti-cancer activity. But drug resistance has greatly affected the clinical use of 5-FU. Overcoming this chemoresistance is a challenge due to the presence of cancer stem cells like cells, cancer recurrence, metastasis, and angiogenesis. In this review, we have systematically discussed the mechanism of 5-FU resistance and advent strategies to increase the sensitivity of 5-FU therapy including resistance reversal. Special emphasis has been given to the cancer stem cells (CSCs) mediated 5-FU chemoresistance and its reversal process by different approaches including the DNA repair inhibition process.
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