A near infrared ratiometric platform based π-extended porphyrin metal-organic framework for O2 imaging and cancer therapy

Photodynamic therapy (PDT) is widely researched in tumor treatment, but its therapeutic effect is affected by oxygen (O2) concentration of tumor site. Here, we developed a Pd-coordinated ?-conjugated extended porphyrin doped porphyrin metal-organic-framework (named as PTP). PTP can achieve near infrared (NIR) O2 concentration ratiometric imaging, solving the problems of short detection wavelengths and influence of selfconcentrations. With the NIR excitation wavelength and the ability of higher singlet oxygen (1O2) generation, PTP can induce PDT more effectively. The efficient PDT also mediates cancer immunogenic cell death (ICD), which combines with the immune checkpoint inhibitor ?PD-1 to achieve obviously cancer suppression and antimetastasis effect. This theranostic NIR ratiometric nanoprobe can be used as a pre-evaluation on the outcome of PDT and high-efficient cancer combined treatment system, which will find great potential in tumor diagnosis and treatment.

Automated summary

A newly developed photosensitizer, PTP, can achieve ratiometric oxygen imaging and induce cancer cell death more effectively through photodynamic therapy, combined with immunotherapy to significantly suppress cancer growth and metastasis.