期刊
BIOMATERIALS
卷 276, 期 -, 页码 -出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.biomaterials.2021.120838
关键词
Burn wound dressing; Dynamic wounds; Double cross-linked; Shape adaptability; Injectable self-healing; Tissue adhesion
资金
- National Key R&D Program of China [2019YFA0905200]
- National Natural Science Foundation of China [21838009, 22008196]
- China Postdoctoral Science Foundation [2019M663951XB]
- Natural Science Foundation of Shaanxi Province, China [2020JQ-570]
A novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond was designed for dynamic burn wounds, showing enhanced physicochemical properties and efficacy, suitable for wounds with irregular shapes.
Burn wounds are one of the most destructive skin traumas that cause more than 180000 deaths each year. Patients with large, irregular burn wounds suffer from slow healing. Dynamic burn wounds have special requirements for hydrogel dressing due to their high frequency movement. To focus on dynamic burn wounds, we designed a novel double cross-linked hydrogel prepared by Schiff base and catechol-Fe3+ chelation bond. The unique double cross-linked structure of the hydrogel resulted in better physicochemical properties and enhanced efficacy. The enhanced physicochemical properties, such as faster gelation time (52 +/- 2 s), stronger mechanical property (535 kPa of G'), enhanced adhesive strength (19.3 kPa) and better self-healing property, made the hydrogel suitable for dynamic wounds. The excellent shape adaptability (97.1 +/- 1.3% of recovery) made the hydrogel suitable for wounds with irregular shapes. The hydrogel exhibited not only biodegradability during the wound healing process but also superior inherent antibacterial activity (100% killing ratio) and hemostatic property. The results showed that the hydrogel shortened the healing time of burn wounds to 13 days, and accelerated the reconstruction of skin structure and function. This double cross-linked multifunctional hydrogel is a promising candidate as a dynamic burn wound dressing.
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