期刊
BIOMARKERS IN MEDICINE
卷 15, 期 8, 页码 597-608出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2020-0654
关键词
autoimmune; biomarkers; constipation; dopamine; fecal transplant; gut– brain axis; Lewy bodies; microbiome; mitophagy; neurodegeneration; neuroimaging; neuroinflammation; oxidative stress; Parkinson’ s disease; reactive gliosis; substantia nigra; vagotomy
资金
- NIH [R01 CA204881, R01 CA206026, P30 CA56036]
- Defense Congressionally Directed Medical Research Program [W81XWH-17-PRCRP-TTSA]
- PhRMA Foundation
- Defense Congressionally Directed Medical Research Programs [W81XWH-17-1-0299, W81XWH-19-1-0263, W81XWH-19-1-0067]
- Courtney Ann Diacont Memorial Foundation
Parkinson's disease is a highly prevalent and irreversible neurodegenerative disorder with no approved biomarkers to reliably identify patients before extensive neuronal damage. Recent research exploring mechanisms underlying PD progression challenges the classic view of PD as a brain-isolated disease, leading to potential new biomarker candidates from multiple sites in the body.
Parkinson's disease (PD) is a highly prevalent and irreversible neurodegenerative disorder that is typically diagnosed in an advanced stage. Currently, there are no approved biomarkers that reliably identify PD patients before they have undergone extensive neuronal damage, eliminating the opportunity for future disease-modifying therapies to intervene in disease progression. This unmet need for diagnostic and therapeutic biomarkers has fueled PD research for decades, but these efforts have not yet yielded actionable results. Recently, studies exploring mechanisms underlying PD progression have offered insights into multisystemic contributions to pathology, challenging the classic perspective of PD as a disease isolated to the brain. This shift in understanding has opened the door to potential new biomarkers from multiple sites in the body. This review focuses on emerging candidates for PD biomarkers in the context of current diagnostic approaches and multiple organ systems that contribute to disease.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据