期刊
BIOMARKERS IN MEDICINE
卷 15, 期 6, 页码 401-412出版社
FUTURE MEDICINE LTD
DOI: 10.2217/bmm-2020-0506
关键词
acute physiology and chronic health evaluation II score; acute respiratory distress syndrome; central nervous system infection; disease severity; long noncoding RNA plasmacytoma variant translocation 1; mortality; predictive value; respiratory infection; sepsis; sequential organ failure assessment score
The study found that lncRNA PVT1 is associated with predicting risk of ARDS and mortality in sepsis patients as an independent factor, and its expression is positively correlated with disease severity.
Aim: We aimed to investigate the association of long noncoding RNA plasmacytoma variant translocation 1 (lncRNA PVT1) expression with acute respiratory distress syndrome (ARDS) risk and its prognostic value for 28-day mortality in sepsis patients. Materials & methods: LncRNA PVT1 expression from 109 sepsis patients and 100 health controls was detected. General sepsis severity was assessed using acute physiology and chronic health evaluation II score and sequential organ failure assessment score. Results: LncRNA PVT1 had an acceptable predictive value for higher ARDS risk, then was identified as an independent risk factor for sepsis ARDS; LncRNA PVT1 expression positively correlated with general disease severity in sepsis patients; LncRNA PVT1 was overexpressed in 28-day deaths compared with 28-day survivors in sepsis patients. Conclusion: LncRNA PVT1 may facilitate the surveillance of ARDS, general disease severity and the prediction of mortality in sepsis patients.
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