期刊
BIOMACROMOLECULES
卷 22, 期 6, 页码 2325-2337出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.biomac.0c01316
关键词
-
资金
- Ministry of Education, Youth and Sports of the Czech Republic [LM2018129, LTC19032, LM2018133]
- Academy of Sciences of the Czech Republic [AV21, VP06, RP10]
- Czech Science Foundation [19-01438S]
- Charles University [602119, 766119]
In this study, polymer tracers for F-19 MRI were modified by introducing a redox-responsive monomer, allowing for changes in physicochemical properties in an oxidative environment. These ROS-responsive polymers have potential applications in theranostic purposes, especially in terms of drug delivery systems sensitive to oxidative environments in tumors or inflamed tissues.
Fluorine-19 magnetic resonance imaging (F-19 MRI) enables detailed in vivo tracking of fluorine-containing tracers and is therefore becoming a particularly useful tool in noninvasive medical imaging. In previous studies, we introduced biocompatible polymers based on the hydrophilic monomer N-(2-hydroxypropyl)methacrylamide (HPMA) and the thermoresponsive monomer N-(2,2-difluoroethyl)acrylamide (DFEA). These polymers have abundant magnetically equivalent fluorine atoms and advantageous properties as F-19 MRI tracers. Furthermore, in this pilot study, we modified these polymers by introducing a redox-responsive monomer. As a result, our polymers changed their physicochemical properties once exposed to an oxidative environment. Reactive oxygen species (ROS)-responsive polymers were prepared by incorporating small amounts (0.9-4.5 mol %) of the N-[2-(feffocenylcarboxamido)ethyllacrylamide (FcCEA) monomer, which is hydrophobic and diamagnetic in the reduced electroneutral (Fe(II), ferrocene) state but hydrophilic and paramagnetic in the oxidized (Fe(III), feffocenium cation) state. This property can be useful for theranostic purposes (therapy and diagnostic purposes), especially, in terms of ROS-responsive drugdelivery systems. In the reduced state, these nanoparticles remain self-assembled with the encapsulated drug but release the drug upon oxidation in ROS-rich tumors or inflamed tissues.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据