期刊
BIOLOGY OF THE CELL
卷 113, 期 8, 页码 329-343出版社
WILEY
DOI: 10.1111/boc.202000148
关键词
Actin; Membrane; Tubule; Vesicle trafficking
类别
资金
- French Agence Nationale de la Recherche [ANR- 18-CE13-0007-01]
- Fondation pour la Recherche Medicale [FDT201904007966]
This review highlights the importance of actomyosin networks in remodeling membrane tubules within living cells, emphasizing the progress made in understanding the underlying mechanisms through in vitro experiments. It shows how mimicking cellular membranes and actin dynamics in controlled conditions sheds light on the regulation of tubule shape.
Inside living cells, the remodelling of membrane tubules by actomyosin networks is crucial for processes such as intracellular trafficking or organelle reshaping. In this review, we first present various in vivo situations in which actin affects membrane tubule remodelling, then we recall some results on force production by actin dynamics and on membrane tubules physics. Finally, we show that our knowledge of the underlying mechanisms by which actomyosin dynamics affect tubule morphology has recently been moved forward. This is thanks to in vitro experiments that mimic cellular membranes and actin dynamics and allow deciphering the physics of tubule remodelling in biochemically controlled conditions, and shed new light on tubule shape regulation.
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