期刊
BIOLOGICAL PSYCHIATRY
卷 89, 期 9, 页码 896-910出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.biopsych.2020.10.016
关键词
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资金
- Amgen Scholars Foundation
- Autism Science Foundation
- National Institute of Mental Health [5P50MH106438-04, R01MH109912]
- Simons Foundation for Autism Research Bridge to Independence Award
- Dennis Weatherstone Predoctoral Fellowship from Autism Speaks [7825]
- ARCS Foundation
- University of California Office of the President [P50-MH106438]
- University of California Davis Research Investments in Science and Engineering Program
- Stanley & Jacqueline Schilling Neuroscience Postdoctoral Research Fellowship
Utilizing a nonhuman primate model exposed to a viral mimic during pregnancy, researchers studied the impact of gene expression in the offspring's brain, identifying 266 unique genes with differential expression in at least one brain region, particularly in the hippocampus. These findings help elucidate how MIA may increase the risk of neuropsychiatric disorders through molecular pathways.
BACKGROUND: Maternal immune activation (MIA) is a proposed risk factor for multiple neuropsychiatric disorders, including schizophrenia. However, the molecular mechanisms through which MIA imparts risk remain poorly understood. A recently developed nonhuman primate model of exposure to the viral mimic poly:ICLC during pregnancy shows abnormal social and repetitive behaviors and elevated striatal dopamine, a molecular hallmark of human psychosis, providing an unprecedented opportunity for studying underlying molecular correlates. METHODS: We performed RNA sequencing across psychiatrically relevant brain regions (prefrontal cortex, anterior cingulate, hippocampus) and primary visual cortex for comparison from 3.5-to 4-year-old male MIA-exposed and control offspring-an age comparable to mid adolescence in humans. RESULTS: We identify 266 unique genes differentially expressed in at least one brain region, with the greatest number observed in hippocampus. Co-expression networks identified region-specific alterations in synaptic signaling and oligodendrocytes. Although we observed temporal and regional differences, transcriptomic changes were shared across first-and second-trimester exposures, including for the top differentially expressed genes-PIWIL2 and MGARP. In addition to PIWIL2, several other regulators of retrotransposition and endogenous transposable elements were dysregulated following MIA, potentially connecting MIA to retrotransposition. CONCLUSIONS: Together, these results begin to elucidate the brain-level molecular processes through which MIA may impart risk for psychiatric disease.
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