4.7 Article

GSpace: an exact coalescence simulator of recombining genomes under isolation by distance

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BIOINFORMATICS
卷 37, 期 20, 页码 3673-3675

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OXFORD UNIV PRESS
DOI: 10.1093/bioinformatics/btab261

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  1. LabEx CeMEB [ANR-10LABX-04-01]
  2. CBGP host platform
  3. Agence Nationale de la Recherche [ANR16-CE02-0008, ANR-19-CE02-0011]

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GSpace is a simulator for genomic data based on a generation-by-generation coalescence algorithm, which takes into account small population size, recombination, and isolation by distance.
Motivation: Simulation-based inference can bypass the limitations of statistical methods based on analytical approximations, but software allowing simulation of structured population genetic data without the classical n-coalescent approximations (such as those following from assuming large population size) are scarce or slow. Results: We present GSpace, a simulator for genomic data, based on a generation-by-generation coalescence algorithm taking into account small population size, recombination and isolation by distance.

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