Integrative transcription start site identification with iTiSS

A Summary: Many experimental approaches have been developed to identify transcription start sites (TSS) from genomic scale data. However, experiment specific biases lead to large numbers of false-positive calls. Here, we present our integrative approach iTiSS, which is an accurate and generic TSS caller for any TSS profiling experiment in eukaryotes, and substantially reduces the number of false positives by a joint analysis of several complementary datasets.

Automated summary

The study introduces a comprehensive approach called iTiSS for accurately identifying TSS in any eukaryotic TSS profiling experiment, reducing false positives by jointly analyzing multiple complementary datasets.