期刊
BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS
卷 1862, 期 4, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bbabio.2021.148377
关键词
Electron bifurcation; Energy efficiency; Flavin; Quinone; Thermodynamic landscape; Electron transfer
资金
- U.S. Department of Energy (DOE) [DE-AC36-08GO28308]
- U.S. Department of Energy, Office of Science, Early Career Program
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences, Physical Biosciences Program
- U.S. Department of Energy, Office of Basic Energy Sciences, Division of Chemical Sciences, Geosciences, and Biosciences [DE-SC0021144]
- U.S. Department of Energy (DOE) [DE-SC0021144] Funding Source: U.S. Department of Energy (DOE)
Electron bifurcation is a biological mechanism that drives thermodynamically unfavorable redox reactions through direct coupling with exergonic reactions. Common in anaerobic metabolism, it helps microorganisms generate high-energy reducing equivalents to sustain life, and recent research has revealed details of the redox energy landscapes of various electron bifurcating enzymes.
Electron bifurcation is a biological mechanism to drive a thermodynamically unfavorable redox reaction through direct coupling with an exergonic reaction. This process allows microorganisms to generate high energy reducing equivalents in order to sustain life and is often found in anaerobic metabolism, where the energy economy of the cell is poor. Recent work has revealed details of the redox energy landscapes for a variety of electron bifurcating enzymes, greatly expanding the understanding of how energy is transformed by this unique mechanism. Here we highlight the plasticity of these emerging landscapes, what is known regarding their mechanistic underpinnings, and provide a context for interpreting their biochemical activity within the physiological framework. We conclude with an outlook for propelling the field toward an integrative understanding of the impact of electron bifurcation.
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