期刊
BIOCHEMICAL PHARMACOLOGY
卷 187, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.bcp.2020.114309
关键词
3R; Primary afferent sensory neurons; Spinal cord microglia; Chronic pain
资金
- JSPS KAKENHI [19H05658, 19K22500]
- AMED-CREST [20gm0910006]
- AMED-BINDS [20am0101091]
- Grants-in-Aid for Scientific Research [19H05658, 19K22500] Funding Source: KAKEN
Chronic pain, especially neuropathic pain, is a significant clinical issue due to the ineffectiveness of available drugs. Research on extracellular ATP and P2 receptors in pain signaling provides insight into the mechanisms underlying chronic pain and potential therapeutic targets.
Chronic pain is a debilitating condition that often occurs following peripheral tissue inflammation and nerve injury. This pain, especially neuropathic pain, is a significant clinical problem because of the ineffectiveness of clinically available drugs. Since Burnstock proposed new roles of nucleotides as neurotransmitters, the roles of extracellular ATP and P2 receptors (P2Rs) in pain signaling have been extensively studied, and ATP-P2R signaling has subsequently received much attention as it can provide clues toward elucidating the mechanisms underlying chronic pain and serve as a potential therapeutic target. This review summarizes the literature regarding the role of ATP signaling via P2X3Rs (as well as P2X2/3Rs) in primary afferent neurons and via P2X4Rs and P2X7Rs in spinal cord microglia in chronic pain, and discusses their respective therapeutic potentials.
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