期刊
EPIDEMIOLOGY AND INFECTION
卷 145, 期 2, 页码 401-412出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S0950268816002417
关键词
Drug injectors; HIV; incidence; LAg; recent infection
资金
- European Social Fund
- Greek national resources
- Hellenic Scientific Society for the study of AIDS and Sexually Transmitted Diseases
- National Institute on Drug Abuse (NIDA) [P30 DA11041, DP1 DA034989]
- International AIDS Society
This analysis assessed the utility of the limiting antigen avidity assay (LAg). Samples of people who inject drugs (PWID) in Greece with documented duration of HIV-1 infection were tested by LAg. A LAg-normalized optical density (ODn) <= 1.5 corresponds to a recency window period of 130 days. The proportion true recent (PTR) and proportion false recent (PFR) were estimated in 28 seroconverters and in 366 samples collected > 6 months after HIV diagnosis, respectively. The association between LAg ODn and HIV RNA level was evaluated in 232 persons. The PTR was 85 . 7%. The PFR was 20 . 8% but fell to 5 . 9% in samples from treatment-naive individuals with long-standing infection (> 1 year), and to 0 in samples with the circulating recombinant form CRF35 AD. A LAg-based algorithm with a PFR of 3 . 3% estimated a similar incidence trend to that calculated by analyses based on HIV-1 seroconversions. In recently infected persons indicated by LAg, the median log(10) HIV RNA level was high (5 . 30, interquartile range 4 . 56-5 . 90). LAg can help identify highly infectious HIV(+) individuals as it accurately identifies recent infections and is correlated with the HIV RNA level. It can also produce reliable estimates of HIV-1 incidence.
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