期刊
BIOCHEMICAL ENGINEERING JOURNAL
卷 168, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.bej.2021.107955
关键词
Porous silica; Chemotherapy-photothermal synergy; Green fluorescence monitoring; Degradability; pH/GSH/NIR-responsive release
资金
- Medical Interdisciplinary Training Program of Henan University [CJ1205A0240013]
S-S bond-doped porous silica nanoparticles with CuS nanocores were prepared as drug carriers for chemical-photothermal synergistic therapy and redox/pH/light triple-response drug release. The synthesized carriers have dendritic pore structure with particle size of about 100 nm and showed good biocompatibility. The introduction of CuS nanocores provided the system with a good photothermal therapy function.
In this work, S-S bond-doped porous silica nanoparticles with CuS nanocores (CuS/OS) were prepared as drug carriers for chemical-photothermal synergistic therapy and redox/pH/light triple-response drug release. The synthesized CuS/OS carriers have dendritic pore structure with particle size of about 100 nm. Tiopronin (MPG) was used as model drug to evaluate the release performance of the carrier. Chitosan (CS) and green fluorescent curcumin (Cur) were used as plugs to seal the loaded drug, which endows the CuS/OS carrier with pH-responsive release and monitoring properties. The obtained MPG-loaded CuS/OS-CS-Cur has pH/GSH/NIR triple responsive release and redox-responsive degradation. The introduction of CuS nanocores gives the CuS/OS system a good photothermal therapy function. The CuS/OS-CS-Cur and its degradation products have good biocompatibility.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据