Morpholino-based peptide oligomers: Synthesis and DNA binding properties

The chemical structure of oligonucleotide analogues dictates the conformation of oligonucleotide analogue oligomers, their ability to hybridize complementary DNA and RNA, their stability to degradation and their pharmacokinetic properties. In a study aimed at investigating new analogues featuring a neutral backbone, we explored the ability of oligomers containing a morpholino-peptide backbone to bind oligonucleotides. Circular Dichroism studies revealed the ability of our oligomers to interact with DNA, molecular modelling studies revealed the interaction responsible for complex stabilization. ? 2021 Elsevier Inc. All rights reserved.

Automated summary

The chemical structure of oligonucleotide analogues determines their interaction with DNA and RNA, and research on new analogues has shown their ability to bind DNA and stabilize complexes.