期刊
BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY
卷 17, 期 -, 页码 730-736出版社
BEILSTEIN-INSTITUT
DOI: 10.3762/bjoc.17.62
关键词
2-azahexatiriene system; carbodiimide; electrocyclization; pyrrolo[2; 3-c]quinoline; trigonoine B
The first total synthesis of the pyrrolo[2,3-c]quinoline alkaloid trigonoine B was achieved through a six-step sequence, providing a framework for the preparation of various N-substituted 4-aminopyrroloquinolines with different biological activities.
The first total synthesis of the pyrrolo[2,3-c]quinoline alkaloid trigonoine B (1) was accomplished via a six-step sequence involving the construction of an N-substituted 4-aminopyrrolo[2,3-c]quinoline framework via electrocyclization of 2-(pyrrol-3-yl)benzene containing a carbodiimide moiety as a 2-azahexatriene system. The employed six-step sequence afforded trigonoine B (1) in 9.2% overall yield. The described route could be employed for the preparation of various N-substituted 4-aminopyrroloquinolines with various biological activities.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据