期刊
BEHAVIORAL AND BRAIN FUNCTIONS
卷 17, 期 1, 页码 -出版社
BMC
DOI: 10.1186/s12993-021-00177-x
关键词
Obsessive– compulsive disorder; Behavior; Brain area; Neuronal activity
资金
- National Key R&D Program of China [2018YFA0108300]
- National Natural Science Foundation of China [81622016, 31571034, 81871048]
- Guangdong Natural Science Foundation [2015A030306019, 2018B030311034]
- Sun Yat-sen University Young Teachers Key Training Project Fund [19ykzd41]
- Guangdong Basic and Applied Basic Research Foundation [2019A1515011308]
- Guangdong Provincial Key R&D Program under Grant Key Technologies for Treatment of Brain Disorders [2018B030332001]
- Guangdong Provincial Key R&D Program under Development of New Tools for Diagnosis and Treatment of Autism [2018B030335001]
The study found that OCD mouse models induced by different drugs exhibited distinct behavioral traits, and further investigation of neuronal activation in specific brain regions suggested that these traits may be mediated by the activation of different brain areas.
Background Obsessive-compulsive disorder (OCD) is a mental disease with heterogeneous behavioral phenotypes, including repetitive behaviors, anxiety, and impairments in cognitive functions. The brain regions related to the behavioral heterogeneity, however, are unknown. Methods We systematically examined the behavioral phenotypes of three OCD mouse models induced by pharmacological reagents [RU24969, 8-hydroxy-DPAT hydrobromide (8-OH-DPAT), and 1-(3-chlorophenyl) piperazine hydrochloride-99% (MCPP)], and compared the activated brain regions in each model, respectively. Results We found that the mouse models presented distinct OCD-like behavioral traits. RU24969-treated mice exhibited repetitive circling, anxiety, and impairments in recognition memory. 8-OH-DPAT-treated mice exhibited excessive spray-induced grooming as well as impairments in recognition memory. MCPP-treated mice showed only excessive self-grooming. To determine the brain regions related to these distinct behavioral traits, we examined c-fos expression to indicate the neuronal activation in the brain. Our results showed that RU24969-treated mice exhibited increased c-fos expression in the orbitofrontal cortex (OFC), anterior cingulate cortex (ACC), prelimbic cortex (PrL), infralimbic cortex (IL), nucleus accumbens (NAc), hypothalamus, bed nucleus of the stria terminalis, lateral division, intermediate part (BSTLD), and interstitial nucleus of the posterior limb of the anterior commissure, lateral part (IPACL), whereas in 8-OH-DPAT-treated mice showed increased c-fos expression in the ACC, PrL, IL, OFC, NAc shell, and hypothalamus. By contrast, MCPP did not induce higher c-fos expression in the cortex than control groups. Conclusion Our results indicate that different OCD mouse models exhibited distinct behavioral traits, which may be mediated by the activation of different brain regions.
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