期刊
BRAIN IMAGING AND BEHAVIOR
卷 10, 期 1, 页码 252-257出版社
SPRINGER
DOI: 10.1007/s11682-015-9389-1
关键词
Spinocerebellar ataxia; Motor impairment; VBM; Cerebellum; Precentral gyrus
类别
资金
- Universidad Nacional Autonoma de Mexico [PAPIIT IN221413]
- Consejo Nacional de Ciencia y Tecnologia [220871]
- National Ataxia Foundation (USA)
Spinocerebellar ataxia type 7 (SCA7) is a progressive neurodegenerative disorder that is accompanied by loss of motor control and macular degeneration. Previous studies have shown cerebellar and pons atrophy as well as functional connectivity changes across the whole brain. Although different MRI modalities have been used to study the degenerative process, little is known about the relationship between the motor symptoms and cerebral atrophy. Twenty-four patients with molecular diagnosis of SCA7 where invited to participate in this study. Ataxia severity was evaluated using the scale for the assessment and rating of ataxia (SARA). Structural magnetic resonance imaging (MRI) brain images were used to obtain the grey matter volume of each participant. As expected, we found a significant negative correlation between the SARA score and the grey matter volume in distinct regions of the cerebellum in the patient group. Additionally, we found significant correlations between the ataxia degree and the degeneration of specific cortical areas in these patients. These findings provide a better understanding of the relationship between gray matter atrophy and ataxia related symptoms that result from the SCA7 mutation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据