☆ 4.5 Article

Nasal expression of SARS-CoV-2 entry receptors in newborns

ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION (2022)

Age-determined expression of priming protease TMPRSS2 and localization of SARS-CoV-2 in lung epithelium

Bryce A. Schuler et al.

Summary: The study found that SARS-CoV-2 primarily infects ciliated cells and type I alveolar epithelial cells in the lungs, with TMPRSS2 expression increasing with age. Analysis of autopsy tissue showed that SARS-CoV-2 RNA is mainly located in specific cells in the respiratory tract and peripheral lung that express TMPRSS2.

JOURNAL OF CLINICAL INVESTIGATION (2021)

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Article Pediatrics

Characteristics and outcomes of neonatal SARS-CoV-2 infection in the UK: a prospective national cohort study using active surveillance

Chris Gale et al.

Summary: This study aimed to describe the incidence, characteristics, transmission, and outcomes of SARS-CoV-2 infection in neonates who received inpatient hospital care in the UK. The findings showed that neonatal SARS-CoV-2 infection was uncommon in babies admitted to hospital, with low likelihood of infection following birth to a mother with perinatal SARS-CoV-2 infection and rare possible vertical transmission. The high proportion of babies from Black, Asian, or minority ethnic groups requires further investigation.

LANCET CHILD & ADOLESCENT HEALTH (2021)

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Letter Medicine, General & Internal