期刊
AQUATIC TOXICOLOGY
卷 234, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.aquatox.2021.105787
关键词
Toxic dinoflagellate; Developmental toxicity; Swimming activity; Apoptosis; Marine medaka
资金
- State Key Laboratory of Marine Pollution (SKLMP)
- Collaborative Research Fund [C1012-15G]
- National Natural Science Foundation of China [41576113]
The study found that exposure to C. tropicalis lysates can have toxic effects on the behavior, physiology, and molecular responses of larval marine medaka, including inhibiting swimming activity, inducing developmental abnormalities, and causing changes in gene expression related to apoptosis, inflammatory response, oxidative stress, and energy metabolism.
Coolia tropicalis is a species of benthic and epiphytic toxic algae, which can produce phycotoxins that intoxicate marine fauna. In this study, the potential toxic effects of C. tropicalis on fish were investigated using larval marine medaka (Oryzias melastigma) as a model to evaluate fish behavior, physiological performance, and stress-induced molecular responses to exposure to two sublethal concentrations (LC10 and LC20) of hydrophilic algal lysates. Exposure to C. tropicalis lysates inhibited swimming activity, activated spontaneous undirected locomotion, altered nerve length ration, and induced early development abnormalities, such as shorter eye diameter, body as well as axon length. Consistent with these abnormalities, changes in the expression of genes associated with apoptosis (CASPASE-3 and BCL-2), the inflammatory response (IL-1 beta and COX-2), oxidative stress (SOD), and energy metabolism (ACHE and VHA), were also observed. This study advances our understanding of the mechanisms of C. tropicalis toxicity in marine fish in the early life stages and contributes to future ecological risk assessments of toxic benthic dinoflagellates.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据