期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 43, 期 -, 页码 225-231出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.etap.2016.03.018
关键词
Geraniol; Drosophila; Parkinson's disease
资金
- University Grants Commission, New Delhi [F.30-1/2013(SA-II)/RA-2012-14-GE-UTT-858]
The role of Geraniol was studied on the transgenic Drosophila model flies expressing normal human alpha synuclein (h-alpha S) in the neurons. Geraniol at final concentration of 10, 20 and 40 mu M were mixed in the diet and the flies were allowed to feed on it for 24 days. The effect of geraniol was studied on the climbing ability, activity pattern, lipid peroxidation, protein carbonyl, glutathione, dopamine content, and glutathione-S-transferase activity in the brains of transgenic Drosophila. The exposure of PD model flies to 10, 20 and 40 mu M of geraniol results in a significant delay in the loss of climbing ability (p < 0.05), improved activity pattern reduced the oxidative stress (p < 0.05) in the brains of transgenic Drosophila as compared to unexposed PD model flies. The results suggest that geraniol is potent in reducing the PD symptoms in transgenic Drosophila model of Parkinson's disease. (C) 2016 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据