期刊
ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY
卷 41, 期 -, 页码 32-38出版社
ELSEVIER
DOI: 10.1016/j.etap.2015.11.009
关键词
Drosophila; Mercury chloride; Midgut; ROS; Vitamin E
资金
- NWAF support grant [Z111021005]
- National Natural Science Foundation of China [31372256]
We used Drosophila as an animal model to study the digestive tract in response to the exposure of inorganic mercury (HgCl2). We found that after oral administration, mercury was mainly sequestered within the midgut. This resulted in increased cell death, which in turn stimulated the tissue regeneration program, including accelerated proliferation and differentiation of the intestinal stem cells (ISCs). We further demonstrated that these injuries correlate closely with the excessive production of the reactive oxygen species (ROS), as vitamin E, an antioxidant reagent, efficiently suppressed the HgCl2-induced phenotypes of midgut and improved the viability. We propose that the Drosophila midgut could serve as a suitable model to study the treatment of acute hydrargyrism on the digestive systems. (C) 2015 Elsevier B.V. All rights reserved.
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