4.7 Article

Protein Transnitrosylation Signaling Networks Contribute to Inflammaging and Neurodegenerative Disorders

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Summary: This study describes mechanistically distinct enzymes that can mediate a series of redox reactions and lead to synapse loss in patients with Alzheimer's disease. These enzymes can form a separate network for aberrant transnitrosylation, which may not be effectively countered by natural selection in the post-reproductive period.

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