Demethoxycurcumin Suppresses Proliferation, Migration, and Invasion of Human Brain Glioblastoma Multiforme GBM 8401 Cells via PI3K/Akt Pathway

Background/Aim: Demethoxycurcumin (DMC), one of the derivatives of curcumin, has been shown to induce apoptotic cell death in many human cancer cell lines. However, there is no available information on whether DMC inhibits metastatic activity in human glioblastoma cancer cells in vitro. Materials and Methods: DMC at 1.0-3.0 ,uM significantly decreased the proliferation of GBM 8401 cells; thus, we used 2.0 ,uM for further investigation regarding anti-metastatic activity in human glioblastoma GBM 8401 cells. Results: The internalized amount of DMC has reached the highest level in GBM 8401 cells after 3 h treatment.

Automated summary

DMC has shown significant inhibitory effect on the proliferation of human glioblastoma cancer cells, with the internalized amount reaching the highest level after 3 hours of treatment.