期刊
ANNUAL REVIEW OF PHYTOPATHOLOGY, VOL 59, 2021
卷 59, 期 -, 页码 239-263出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-phyto-020620-095952
关键词
regulated cell death; immune signaling; plant disease resistance; NLR; ion channel
资金
- National Science Foundation of China [31830019]
- State Key Laboratory of Plant Genomics [SKLPG2016B-2]
Nucleotide-binding leucine-rich repeat receptors (NLRs) are the largest class of immune receptors in plants, playing a crucial role in plant surveillance by forming resistosomes to activate immune signaling and regulate cell death. Recent research has also found intimate connections between NLRs and surface receptors in immune signaling, advancing our understanding of the plant immune system.
Nucleotide-binding leucine-rich repeat receptors (NLRs) are the largest class of immune receptors in plants. They play a key role in the plant surveillance system by monitoring pathogen effectors that are delivered into the plant cell. Recent structural biology and biochemical analyses have uncovered how NLRs are activated to form oligomeric resistosomes upon the recognition of pathogen effectors. In the resistosome, the signaling domain of the NLR is brought to the center of a ringed structure to initiate immune signaling and regulated cell death (RCD). The Nterminus of the coiled-coil (CC) domain of the NLR protein HOPZ-ACTIVATED RESISTANCE 1 likely forms a pore in the plasma membrane to trigger RCD in a way analogous to animal pore-forming proteins that trigger necroptosis or pyroptosis. NLRs that carry TOLL-INTERLEUKIN1-RECEPTOR as a signaling domain may also employ pore-forming resistosomes for RCD execution. In addition, increasing evidence supports intimate connections between NLRs and surface receptors in immune signaling. These new findings are rapidly advancing our understanding of the plant immune system.
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