期刊
ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, VOL 23, 2021
卷 23, 期 -, 页码 433-459出版社
ANNUAL REVIEWS
DOI: 10.1146/annurev-bioeng-082020-035644
关键词
aptamer recognition; biosensors; point-of-care diagnostics; global health; optical sensors; electrochemical sensors
资金
- National Science Foundation [1944167]
- Directorate For Engineering
- Div Of Chem, Bioeng, Env, & Transp Sys [1944167] Funding Source: National Science Foundation
Research on aptamer-based biosensors for health-relevant analytical targets has grown rapidly since the early 2000s. Applications include detection of proteins, small molecules, circulating cancer cells, and other health-related targets. One of the main challenges is bringing these new devices from the laboratory to the market.
Since aptamers were first reported in the early 2000s, research on their use for the detection of health-relevant analytical targets has exploded. This review article provides a brief overview of the most recent developments in the field of aptamer-based biosensors for global health applications. The review provides a description of general aptasensing principles and follows up with examples of recent reports of diagnostics-related applications. These applications include detection of proteins and small molecules, circulating cancer cells, whole-cell pathogens, extracellular vesicles, and tissue diagnostics. The review also discusses the main challenges that this growing technology faces in the quest of bringing these new devices from the laboratory to the market.
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