4.7 Editorial Material

How low can you go? PD-L1 expression as a biomarker in trials of cancer immunotherapy

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A pan-cancer analysis of PD-L1 immunohistochemistry and gene amplification, tumor mutation burden and microsatellite instability in 48,782 cases

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Summary: The study examined PD-L1 expression in a wide variety of tumor types and its relationship with MSI, TMB, and CD274 gene amplification. It found a high correlation between PD-L1 expression and these biomarkers, as well as identified four unique disease subsets based on PD-L1 and TMB status. The analysis of over 48,000 cases provides valuable insights for potential response to immunotherapy.

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