期刊
ANNALS OF EPIDEMIOLOGY
卷 56, 期 -, 页码 61-+出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.annepidem.2020.11.007
关键词
Registry; Population-based; Hospital-based; Mortality; Prevalence
资金
- CDC National Center on Birth Defects and Developmental Disabilities [5U01DD000491]
- Arkansas Biosciences Institute [037062]
- Dutch Ministry of Welfare, Health and Sports
- Instituto de Salud Carlos III, Ministry of Science and Innovation, of Spain
- Direzione Diritti di cittadinanza e coesione socialeRegione Toscana
- Czech Ministry of Health [AZV 17-29622A]
- Public Health Wales
- Fundacion 1000 sobre Defectos Congenitos, of Spain
This study analyzed the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH) using data from 25 hospital-and population-based surveillance programs in 19 countries. The study found a slight increase in CDH prevalence between 2001 and 2012, but a decrease in mortality rates over time. Most deaths due to CDH occurred within the first week of life.
Purpose: This study determined the prevalence, mortality, and time trends of children with congenital diaphragmatic hernia (CDH) . Methods: Twenty-five hospital-and population-based surveillance programs in 19 International Clearinghouse for Birth Defects Surveillance and Research member countries provided birth defects mortality data between 1974 and 2015. CDH cases included live births, stillbirths, or elective termination of pregnancy for fetal anomalies. Prevalence, cumulative mortality rates, and 95% confidence intervals (CIs) were calculated using Poisson regression and a Kaplan-Meier product-limit method. Joinpoint regression analyses were conducted to assess time trends.& nbsp; Results: The prevalence of CDH was 2.6 per 10,000 total births (95% CI: 2.5-2.7), slightly increasing between 2001 and 2012 (average annual percent change = 0.5%; 95% CI:-0.6 to 1.6). The total percent mortality of CDH was 37.7%, with hospital-based registries having more deaths among live births than population-based registries (45.1% vs. 33.8%). Mortality rates decreased over time (average annual percent change =-2.4%; 95% CI:-3.8 to 1.1). Most deaths due to CDH occurred among 2-to 6-day-old infants for both registry types (36.3%, hospital-based; 12.1%, population-based).& nbsp; Conclusions: The mortality of CDH has decreased over time. Mortality remains high during the first week and varied by registry type.& nbsp; (c) 2020 Elsevier Inc. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据