4.3 Article

Alteration of fear behaviors in sleep-deprived adolescent rats: increased fear expression and delayed fear extinction

期刊

ANIMAL CELLS AND SYSTEMS
卷 25, 期 2, 页码 83-92

出版社

TAYLOR & FRANCIS LTD
DOI: 10.1080/19768354.2021.1902854

关键词

Adolescence; fear conditioning; fear extinction; hyperactivity; sleep

资金

  1. Ministry of Education of the Republic of Korea
  2. National Research Foundation of Korea [NRF-2017S1A5A2A01026454]
  3. National Research Foundation of Korea [2017S1A5A2A01026454] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)

向作者/读者索取更多资源

Sleep disruption due to stress can impact emotional memory processing, with sleep disturbances being common in PTSD. Rapid eye movement sleep deprivation in adolescent rats has been shown to increase locomotor activity and anhedonic behavior, as well as enhance fear expression and delay fear extinction, potentially leading to a more severe PTSD-like phenotype.
Disruption of sleep due to acute or chronic stress can lead to changes in emotional memory processing. Sleep disturbances are highly prevalent in post-traumatic stress disorder (PTSD), but still, the contribution of sleep deprivation on the susceptibility to PTSD has received little attention. To determine whether rapid eye movement sleep deprivation (SD) alters the development of fear expression or fear-associated memory impairment in adolescent rats, we performed animal emotional behavior tests using an SD animal model with the flowerpot technique. SD rats showed an increase in locomotor activity frequency and a decrease in sucrose consumption compared to control rats. An increase in freezing behavior during shock trials was observed in SD rats. Noticeably, it was observed that when applying the SD condition after fear stimuli exposure, fear extinction was delayed more in SD rats than in control rats. Overall, these results indicate that SD in adolescent rats leads to increased locomotor activity and anhedonic behavior, as well as increased fear expression and delayed fear extinction, suggesting that SD would lead to increased severity of PTSD-like phenotype.

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