期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 40, 页码 21624-21634出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202105469
关键词
carbanions; photocatalysis; Umpolung; Wolff-Kishner reaction
资金
- German Science Foundation (DFG) [KO 1537/18-1]
- China Scholarship Council (CSC) [201606280052]
- Projekt DEAL
The article summarizes recent progress in the generation of alkyl carbanions through catalytic carbonyl Umpolung, discussing two different catalytic approaches and their reaction scope, mechanistic insights, synthetic applications, and potential future developments.
Carbonyl Umpolung is a powerful strategy in organic chemistry to construct complex molecules. Over the last few years, versatile catalytic approaches for the generation of acyl anion equivalents from carbonyl compounds have been developed, but methods to obtain alkyl carbanions from carbonyl compounds in a catalytic fashion are still at an early stage. This Minireview summarizes recent progress in the generation of alkyl carbanions through catalytic carbonyl Umpolung. Two different catalytic approaches can be utilized to enable the generation of alkyl carbanions from carbonyl compounds: the catalytic Wolff-Kishner reaction and the catalytic single-electron reduction of carbonyl compounds and imines. We discuss the reaction scope, mechanistic insights, and synthetic applications of the methods as well as potential future developments.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据