期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 28, 页码 15436-15444出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202102286
关键词
cell selectivity; membrane camouflage; metabolic glycoengineering; metal-organic frameworks
资金
- National Key R&D Program of China [2019YFA0709202]
- Natural Science Foundation of China [21820102009, 91856205, 21871249, CAS QYZDJ-SSW-SLH052]
The use of cancer cell membrane-camouflaged metal-organic frameworks enabled the selective metabolic glycan labeling of cancer cells in vivo, targeting homotypic cells and different breast cancer subtypes. This strategy could have great potential for personalized diagnosis and therapy through utilizing cancer-tissue-derived cell membranes.
Metabolic glycan labeling (MGL) followed by bioorthogonal chemistry provides a powerful tool for tumor imaging and therapy. However, selectively metabolic labeling of cells or tissues of interest remains a challenge. Particularly, owing to tumor heterogeneity including tumor subtypes and interpatient heterogeneity, it is far more difficult to realize tumor-cell-selective metabolic labeling for precise diagnosis. Inspired by nature, we designed azidosugar-functionalized metal-organic frameworks camouflaged with cancer cell membranes to accomplish cancer-cell-selective MGL in vivo. With abundant receptors, this biomimetic platform not only selectively targets homotypic cells but also realizes different breast cancer subtype-selective MGL. Moreover, the endo/lysosomal-escaped ZIF-8 can make azidosugar escape from lysosomes and accelerate its metabolic incorporation. This strategy also takes advantage of cancer-tissue-derived cell membranes, which may have huge potential for personalized diagnosis and therapy.
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