期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 27, 页码 15013-15019出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202102169
关键词
chemical reaction network; DNA computing; DNA switching circuits; soft matter
资金
- National Key Research and Development Program of China [2018YFE0113200]
- National Science Foundation of China [22074041]
- Shanghai Rising-Star Program [19QA1403000]
This study successfully controls the size change of microgels and adjusts expansion behaviors to adapt to diverse environments by integrating stimuli-responsive soft materials with multi-mode reconfigurable DNA-based chemical reaction circuits. The use of pH-responsive intramolecular conformational switches for regulating DNA strand displacement reactions allows for the construction of dynamic chemical reaction networks with diverse pathways.
Developing smart material systems for performing different tasks in diverse environments remains challenging. Here, we show that by integrating stimuli-responsive soft materials with multi-mode reconfigurable DNA-based chemical reaction circuits (D-CRCs), it can control size change of microgels with multiple reaction pathways and adapt expansion behaviors to meet diverse environments. We first use pH-responsive intramolecular conformational switches for regulating DNA strand displacement reactions (SDRs). The ability to regulate SDRs with tunable pH-dependence allows to build dynamic chemical reaction networks with diverse reaction pathways. We confirm that the designed DNA switching circuits are reconfigurable at different pH and perform different logic operations, and the swelling of DNA switching circuit-integrated microgel systems can be programmably directed by D-CRCs. Our approach provides insight into building smart responsive materials and fabricating autonomous soft robots.
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