期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 23, 页码 12911-12917出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202101378
关键词
DNA nanostructures; DNA nanotechnology; polymers; reconfiguration; self-assembly
资金
- Associazione Italiana per la Ricerca sul Cancro, AIRC [21965]
- European Research Council, ERC [819160]
- European Research Council (ERC) [819160] Funding Source: European Research Council (ERC)
Nature uses non-covalent interactions to achieve structural dynamic reconfiguration of biopolymers. By utilizing the programmability of DNA/DNA interactions, researchers demonstrated the rational design of orthogonal DNA-based addressable tiles that can be reconfigured by external inputs. The study shows that by adding specific inputs sequentially, it is possible to reorganize the formed structures into well-defined distributions, offering a new approach to the field of supramolecular polymers.
Nature uses non-covalent interactions to achieve structural dynamic reconfiguration of biopolymers. Taking advantage of the programmability of DNA/DNA interactions we report here the rational design of orthogonal DNA-based addressable tiles that self-assemble into polymer-like structures that can be reconfigured by external inputs. The different tiles share the same sticky ends responsible for self-assembly but are rationally designed to contain a specific regulator-binding domain that can be orthogonally targeted by different DNA regulator strands. We show that by sequentially adding specific inputs it is possible to re-organize the formed structures to display well-defined distributions: homopolymers, random and block structures. The versatility of the systems presented in this study shows the ease with which DNA-based addressable monomers can be designed to create reconfigurable micron-scale DNA structures offering a new approach to the growing field of supramolecular polymers.
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