期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 19, 页码 10620-10625出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202016051
关键词
alkylation; copper; ketones; organocatalysis; radicals
资金
- JSPS KAKENHI in Hybrid Catalysis for Enabling Molecular Synthesis on Demand [JP20H04823]
This study developed an efficient method for the tertiary alkylation of a ketone using an alpha-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system, allowing the addition of a tertiary alkyl radical to an enamine. Mechanistic studies indicated that the catalytically generated enamine plays a key role in the catalytic cycle, enabling the synthesis of substituted 1,4-dicarbonyl compounds containing quaternary carbons with various alkyl chains.
Herein, we report an efficient method for the tertiary alkylation of a ketone by using an alpha-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system. This dual catalyst system enables the addition of a tertiary alkyl radical to an enamine. Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4-dicarbonyl compounds containing quaternary carbons bearing various alkyl chains.
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