4.8 Article

Direct α-Tertiary Alkylations of Ketones in a Combined Copper-Organocatalyst System

期刊

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 19, 页码 10620-10625

出版社

WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202016051

关键词

alkylation; copper; ketones; organocatalysis; radicals

资金

  1. JSPS KAKENHI in Hybrid Catalysis for Enabling Molecular Synthesis on Demand [JP20H04823]

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This study developed an efficient method for the tertiary alkylation of a ketone using an alpha-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system, allowing the addition of a tertiary alkyl radical to an enamine. Mechanistic studies indicated that the catalytically generated enamine plays a key role in the catalytic cycle, enabling the synthesis of substituted 1,4-dicarbonyl compounds containing quaternary carbons with various alkyl chains.
Herein, we report an efficient method for the tertiary alkylation of a ketone by using an alpha-bromocarbonyl compound as the tertiary alkyl source in a combined Cu-organocatalyst system. This dual catalyst system enables the addition of a tertiary alkyl radical to an enamine. Mechanistic studies revealed that the catalytically generated enamine is a key intermediate in the catalytic cycle. The developed method can be used to synthesize substituted 1,4-dicarbonyl compounds containing quaternary carbons bearing various alkyl chains.

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