期刊
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
卷 60, 期 22, 页码 12560-12568出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/anie.202102893
关键词
asymmetric optical properties; controllable assembly; microRNA-21; SERS-based ratiometric detection; symmetry-breaking nanomaterials
资金
- National Natural Science Foundation of China [22027805, 21874024]
- National Key R&D Program of China [2020YFA0210800]
- joint re-search projects of Health and Education Commission of Fujian Province [2019-WJ-20]
- Natural Science Foundation of Fujian Province [2020J02012]
The study showed that Janus nanogap gold nanoparticles with varying proportions of Au shell coverage exhibit asymmetric optical behavior, with tunability depending on the degree of shell coverage and structural asymmetry. By tuning hydrophilic and hydrophobic polymer brushes, shell-to-shell or core-to-core structures can be formed, leading to enhanced electromagnetic field effects. Additionally, the use of DNA linkers enabled the successful fabrication of dimeric nanostructures.
Janus nanogap gold nanoparticles (JAuNNPs) with varying proportions of Au shell coverage of (ca. 100/75/50/25 %) are presented. The internal nanogap between the partial Au shell and core caused asymmetric optical behavior; tunability depends on the degree of Au shell coverage and structural asymmetry. The shell-to-shell or core-to-core JAuNNDs(50 %) were self-assembled from amphiphilic JAuNNPs(50 %) by tuning the hydrophilic and hydrophobic polymer brushes on the Au core or shell. The positions of electromagnetic field enhancement of JAuNNDs varied with geometrical configurations because of hybridized plasmonic coupling effects. Furthermore, DNA linkers were utilized to form JAuNND(12)(50 %). By combining with Raman molecules, ratiometric SERS signals could be generated, enabling JAuNND(12)(50 %) to image the distribution of miR-21 in living cells and tumors. Asymmetric JAuNNPs allowed facile conjugation of various linkage molecules to fabricate dimeric nanostructures.
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