期刊
ANALYTICAL CHEMISTRY
卷 93, 期 16, 页码 6414-6420出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.analchem.0c05407
关键词
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资金
- National Natural Science Foundation of China [12075164, 21874097, 81972964]
- National Key Research Program of China [2018YFA0208800]
- Suzhou Administration of Science and Technology [sys2018021]
- Wujiang Science and Education Project [wwk201709]
- People's Livelihood Science and Technology of Suzhou [SS201850]
- Scientific Research Program for Young Talents of China National Nuclear Corporation
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
The development of novel iodinated bovine serum albumin nanoparticles for computed tomography (CT) imaging and repair of acute gastritis based on gastritic microenvironment has shown promising results. These pH-sensitive nanoparticles can sediment under acidic conditions and be uniformly distributed in the defected mucosa through phagocytosis of inflammatory cells. The nanoparticles have potential in accurate diagnosis and treatment of gastritis in the early stage by repairing atrophic gastric mucosa and enhancing CT images.
The development of a specific and noninvasive technology for understanding gastritic response together with efficient therapy is an urgent clinical issue. Herein, we fabricated a novel iodinated bovine serum albumin (BSA) nanoparticle based on gastritic microenvironment for computed tomography (CT) imaging and repair of acute gastritis. Derived from the characteristic mucosa defect and inflammatory cell (e.g., macrophage and neutrophil) infiltration in acute gastritis, the pH-sensitive nanoparticles can sedimentate under acidic conditions and be uniformly distributed in the defected mucosal via the phagocytosis of inflammatory cells. Hence, enhanced CT images can clearly reveal the mucosal morphology in the nanoparticle-treated gastritic rat over a long time window comparison with nanoparticle-treated healthy rats and clinical small-molecule-treated gastritic rat. In addition, we have discovered that nanoparticles can repair the atrophic gastric mucosa to a normal state. This repair process mainly stems from inflammatory immune response caused by phagocytized nanoparticles, such as the polarization of proinflammatory macrophages (M1) to anti-inflammatory macrophages (M2). The biocompatible nanoparticles that avoid the inherent defects of the clinical small molecules have great potential for accurate diagnosis and treatment of gastritis in the early stage.
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