期刊
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE
卷 104, 期 6, 页码 2165-2168出版社
AMER SOC TROP MED & HYGIENE
DOI: 10.4269/ajtmh.20-1239
关键词
-
资金
- Defense Malaria Assistance Program
- Defense Health Agency Research and Development Program [D1428]
This study found that Anopheles mosquitoes fed on ivermectin-treated cattle had higher mortality rates compared to control groups, indicating the potential of ivermectin to increase mortality rates of vector species, particularly over biologically relevant time periods.
Ivermectin is a low-cost and nontoxic mosquitocide that may have a role in malaria elimination. However, the extent to which this drug impacts the mortality of Anopheles dirus and Anopheles epiroticus, two important malaria vectors in Southeast Asia, is unknown. This study compared and quantified anopheline mortality after feeding on ivermectin-treated cattle and control cattle in Vietnam. Local anopheline colonies fed on cattle 1 to 3, 6 to 8,13 to 15, 20 to 22, and 28 to 30 days after injection (DAI) with ivermectin (intervention) or saline (control). An. dirus that fed on ivermectintreated cattle had higher mortality rates than controls for up to 20 DAI (P < 0.05); An. epiroticus that fed on ivermectintreated cattle had consistently higher mortality rates than controls for up to 8 DAI (P < 0.05). Feeding on ivermectin-treated cattle increased the mortality rate of these vector species for biologically relevant time periods. Therefore, ivermectin has the potential to become an important tool for integrated vector management.
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