Updates and Ongoing Challenges in Imaging of Multiple Myeloma: AJR Expert Panel Narrative Review

Advances in the understanding and treatment of multiple myeloma have led to the need for more sensitive and accurate imaging of intramedullary and extramedullary disease. This role of imaging is underscored by recently revised imaging recommendations of the International Myeloma Working Group (IMWG). This narrative review discusses these recommendations from the IMWG for different disease stages, focusing on advanced whole-body modalities, and addresses related challenges and controversies. In the recommendations, whole-body low-dose CT is central in initial patient assessment, replacing the conventional skeletal survey. Although the recommendations favor MRI for diagnosis because of its superior sensitivity and utility in identifying myeloma-defining events, FDG PET/CT is recommended as the modality of choice for assessing treatment response. Consensus opinions are offered regarding the role of imaging in multiple myeloma for characterization of disease distribution, determination of prognosis, and response evaluation.

Automated summary

Advancements in understanding and treating multiple myeloma have emphasized the necessity for more sensitive and accurate imaging of intramedullary and extramedullary diseases. The updated imaging recommendations by the International Myeloma Working Group highlight the importance of imaging at different disease stages, particularly advanced whole-body modalities, while also addressing related challenges and controversies.