4.7 Article

A comparison of complementary measures of vitamin B6 status, function, and metabolism in the European Prospective Investigation into Cancer and Nutrition (EPIC) study

期刊

AMERICAN JOURNAL OF CLINICAL NUTRITION
卷 114, 期 1, 页码 338-347

出版社

ELSEVIER SCIENCE INC
DOI: 10.1093/ajcn/nqab045

关键词

vitamin B6; PLP; dietary biomarkers; transsulfuration pathway; kynurenine pathway

资金

  1. Imperial College London President's PhD Scholarship
  2. Cancer Research UK Population Research Fellowship
  3. WCRF [2013/1005]
  4. European Commission (DG-SANCO)
  5. International Agency for Research on Cancer
  6. Danish Cancer Society (Denmark)
  7. Ligue Contre le Cancer (France)
  8. Institut Gustave Roussy (France)
  9. Mutuelle Generale de l'Education Nationale (France)
  10. Institut National de la Sante et de la Recherche Medicale (INSERM) (France)
  11. German Cancer Aid (Germany)
  12. German Cancer Research Center (DKFZ) (Germany)
  13. Federal Ministry of Education and Research (BMBF) (Germany)
  14. DeutscheKrebshilfe (Germany)
  15. DeutschesKrebsforschungszentrum (Germany)
  16. Federal Ministry of Education and Research (Germany)
  17. Associazione Italiana per la Ricerca sul Cancro-AIRC-Italy (Italy)
  18. National Research Council (Italy)
  19. Dutch Ministry of Public Health, Welfare and Sports (VWS) (The Netherlands)
  20. Netherlands Cancer Registry (NKR) (The Netherlands)
  21. LK Research Funds (The Netherlands)
  22. Dutch Prevention Funds (The Netherlands)
  23. Dutch ZON (Zorg Onderzoek Nederland) (The Netherlands)
  24. World Cancer Research Fund (WCRF) (The Netherlands)
  25. Statistics Netherlands (The Netherlands)
  26. Health Research Fund (FIS-ISCIII) (Spain)
  27. Regional Government of Andalucia (Spain)
  28. Regional Government of Asturias (Spain)
  29. Regional Government of Basque Country (Spain)
  30. Regional Government of Murcia (Spain)
  31. Regional Government of Navarra (Spain)
  32. Catalan Institute of Oncology (Barcelona) (Spain)
  33. Swedish Cancer Society (Sweden)
  34. Swedish Research Council (Sweden)
  35. County Council of Skane (Sweden)
  36. County Council of Vasterbotten (Sweden)
  37. Cancer Research UK (United Kingdom) [14136, C8221/A19170, C8221/A29017]
  38. Medical Research Council (United Kingdom) [1000143, MR/M012190/1]

向作者/读者索取更多资源

This study found that vitamin B6 intake was most strongly associated with PLP concentration, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr. PAr was most sensitive to age, while HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers.
Background: Vitamin B6 insufficiency has been linked to increased risk of cancer and other chronic diseases. The circulating concentration of pyridoxal 5'-phosphate (PLP) is a commonly used measure of vitamin B6 status. Ratios of substrates indicating PLP coenzymatic function and metabolism may be useful complementary measures to further explore the role of vitamin B6 in health. Objectives: We explored the sensitivity of 5 outcomes, namely PLP concentration, homocysteine:cysteine (Hcy:Cys), cystathionine:cysteine (Cysta:Cys), the 3'-hydroxykynurenine ratio (HKr), and the 4-pyridoxic acid ratio (PAr) to vitamin B6 intake as well as personal and lifestyle characteristics. Medthods: Dietary intake and biomarker data were collected from participants from 3 nested case-control studies within the European Prospective Investigation into Cancer and Nutrition (EPIC). Bayesian regression models assessed the associations of the 5 biomarker outcomes with vitamin B6 intake and personal and lifestyle covariates. Analogous models examined the relations of Hcy:Cys, Cysta:Cys, and HKr with PLP. Results: In total, 4608 participants were included in the analyses. Vitamin B6 intake was most strongly associated with PLP, moderately associated with Hcy:Cys, Cysta:Cys, and HKr, and not associated with PAr (fold change in marker given a doubling of vitamin B6 intake: PLP 1.60 [95% credible interval (CrI): 1.50. 1.71]; Hcy:Cys 0.87 [95% CrI: 0.84. 0.90]; Cysta:Cys 0.89 [95% Cr1: 0.84. 0.94]; HKr 0.88 [95% Cr1: 0.85, 0.91]; PAr 1.00 [95% CrI: 0.95, 1.05]). PAr was most sensitive to age, and HKr was least sensitive to BMI and alcohol intake. Sex and menopause status were strongly associated with all 5 markers. Conclusions: We found that 5 different markers, capturing different aspects of vitamin B6-related biological processes, varied in their associations with vitamin B6 intake and personal and lifestyle predictors.

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