4.7 Article

Harmonizing neuropsychological assessment for mild neurocognitive disorders in Europe

期刊

ALZHEIMERS & DEMENTIA
卷 18, 期 1, 页码 29-42

出版社

WILEY
DOI: 10.1002/alz.12365

关键词

Alzheimer' s disease; cognitive assessment; diagnosis; mild cognitive impairment; mild neurocognitive disorders; standard neuropsychological assessment

资金

  1. Swiss National Science Foundation [ISZEZO_180198]
  2. Alzheimer Forum Switzerland
  3. MindMaze
  4. EU-EFPIA Innovative Medicines Initiatives 2 Joint Undertaking [115952]
  5. Innovative Medicine Initiative Joint Undertaking
  6. ZONmW
  7. NIH [U01 AG016976]
  8. NHMRC Australia
  9. Italian Ministry of Health

向作者/读者索取更多资源

An expert consensus has been reached on harmonizing the diagnosis of neurocognitive disorders across European countries and potentially beyond, by defining a standardized assessment battery and methodology for obtaining consistent normative data.
Introduction Harmonized neuropsychological assessment for neurocognitive disorders, an international priority for valid and reliable diagnostic procedures, has been achieved only in specific countries or research contexts. Methods To harmonize the assessment of mild cognitive impairment in Europe, a workshop (Geneva, May 2018) convened stakeholders, methodologists, academic, and non-academic clinicians and experts from European, US, and Australian harmonization initiatives. Results With formal presentations and thematic working-groups we defined a standard battery consistent with the U.S. Uniform DataSet, version 3, and homogeneous methodology to obtain consistent normative data across tests and languages. Adaptations consist of including two tests specific to typical Alzheimer's disease and behavioral variant frontotemporal dementia. The methodology for harmonized normative data includes consensus definition of cognitively normal controls, classification of confounding factors (age, sex, and education), and calculation of minimum sample sizes. Discussion This expert consensus allows harmonizing the diagnosis of neurocognitive disorders across European countries and possibly beyond.

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