期刊
ALZHEIMERS & DEMENTIA
卷 17, 期 11, 页码 1818-1831出版社
WILEY
DOI: 10.1002/alz.12352
关键词
age; all-cause dementia; Alzheimer's disease; COVID-19; Parkinson's disease; prospective cohort study; risk factors; UK Biobank
资金
- Fundacao de Amparo a Pesquisa do Estado do Rio de Janeiro (FAPERJ) [210.257/2020]
- National Institute for Translational Neuroscience
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2018/23693-5]
- Fundacao Butantan
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [306646/2019-6, 308638/2013-1]
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [18/23693-5] Funding Source: FAPESP
Dementia and Alzheimer's disease are independent risk factors for disease severity and death in COVID-19.
Introduction Dementia has been associated with COVID-19 prevalence, but whether this reflects higher infection, older age of patients, or disease severity remains unclear. Methods We investigated a cohort of 12,863 UK Biobank community-dwelling individuals > 65 years old (1814 individuals >= 80 years old) tested for COVID-19. Individuals were stratified by age to account for age as a confounder. Risk factors were analyzed for COVID-19-positive diagnosis, hospitalization, and death. Results All-cause dementia, Alzheimer's disease (AD), and Parkinson's disease (PD) were associated with COVID-19-positive diagnosis, and all-cause dementia and AD remained associated in individuals >= 80 years old. All-cause dementia, AD, or PD were not risk factors for overall hospitalization, but increased the risk of hospitalization of COVID-19 patients. All-cause dementia and AD increased the risk of COVID-19-related death, and all-cause dementia was uniquely associated with increased death in >= 80-year-old patients. Discussion All-cause dementia and AD are age-independent risk factors for disease severity and death in COVID-19.
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