期刊
AGE AND AGEING
卷 50, 期 4, 页码 1038-1047出版社
OXFORD UNIV PRESS
DOI: 10.1093/ageing/afab096
关键词
COVID-19; SARS-CoV-2; seroprevalence; seropositivity; nursing homes; older adults; occupational
资金
- Health Council of the Community of Madrid
The study highlights the high prevalence of COVID-19 among residents in nursing homes, especially those who are frail and have comorbidities. Factors associated with seropositivity among staff include age, obesity, job type, workplace seroprevalence, and contact with external COVID-19 cases. Strengthening control measures is crucial to prevent COVID-19 transmission in care facilities.
Background: Nursing homes for older adults have concentrated large numbers of severe cases and deaths for coronavirus disease 2019 (COVID-19). Methods: Point seroprevalence study of nursing homes to describe the demography and characteristic of severe acute respiratory syndrome by coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG)-positive residents and staff. Results: Clinical information and blood samples were available for 9,332 residents (mean age 86.7 +/- 8.1 years, 76.4% women) and 10,614 staff (mean age 45.6 +/- 11.5, 86.2% women). Up to 84.4% of residents had frailty, 84.9% co-morbidity and 69.3% cognitive impairment; 65.2% of workers were health-aides. COVID-19 seroprevalence was 55.4% (95% confidence interval (CI), 54.4-56.4) for older adults and 31.5% (30.6-32.4) for staff. In multivariable analysis, frailty of residents was related with seropositivity (odds ratio (OR): 1.19, P = 0.02). In the case of staff, age > 50 years (2.10, P < 0.001), obesity (1.19, P = 0.01), being a health-aide (1.94, P < 0.001), working in a center with high seroprevalence in residents (3.49, P < 0.001) and contact with external cases of COVID-19 (1.52, P < 0.001) were factors associated with seropositivity. Past symptoms of COVID-19 were good predictors of seropositivity for residents (5.41, P < 0.001) and staff (2.52, P < 0.001). Conclusions: Level of dependency influences risk of COVID-19 among residents. Individual and work factors, contacts outside the nursing home are associated with COVID-19 exposure in staff members. It is key to strengthen control measures to prevent the introduction of COVID-19 into care facilities from the community.
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